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چکیده
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Abstract Background and Aim: Studies have investigated the clinical effectiveness of exercise interventions in Alzheimer's patients and highlight the potential benefits of exercise in improving cognitive function. Based on this, the investigation of different forms of sports interventions in the field of Alzheimer's disease treatment with the aim of reducing hippocampal tissue necrosis was designed in this study. Materials and methods: 40 Wistar rats were randomly divided into 5-groups: healthy control, Alzheimer's control, Swim, Resi, and Swim+Resi. Alzheimer's disease was induced by intraperitoneal injection of trimethyltin chloride (8 mg/kg). Two weeks after the injection and confirmation of Alzheimer's, the training protocols of Swim (5-sessions/week, the first to the fourth week incrementally from 5-15-min to 45-min of swimming, the fifth to the twelfth week 60-min of swimming), Resi (5-sessions/week, the first week of familiarization with the training, week 2; 30%, week3-5; 70 to 90%, week6-8; 100 to 110%, week9-10; 120 to 130%, and week11-12; 140 to 150% of body weight), Swim+Resi were implemented for 12-weeks (2 days/week Resi and 3 days/week Swim). 48-h after the interventions, rats was dissected and hippocampal tissue was extracted to check the number of necrotic cells. Ethical Considerations: The study protocol was approved by the Animal Care and Use Committee of Bu Ali Sina University, Hamedan (code: IR.BASU.REC.1401.019.). Results: The results showed that the Alzheimer's-control group had significantly more necrotic cells compared to the healthy-control group (p=0.002). 12 weeks of combined training caused a significant decrease in the number of necrotic cells in the hippocampus of the Swim+Resi group compared to the Alzheimer-control group (p=0.016). Conclusion: The synergistic effects of endurance swimming and resistance training with weights may offer a comprehensive approach to addressing the multifaceted pathological mechanisms underlying Alzheimer's disease in the hippocampus, potentially involving the modulation of necroptosis and other cell death pathways.
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