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چکیده
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Nanoparticle-based drug delivery systems have significantly transformed the field of medicine by providing more targeted, efficient, and safer delivery of therapeutic agents. These systems address the limitations of traditional drug delivery methods, such as off-target effects, low solubility, and rapid clearance. At the heart of nanoparticle drug delivery systems are targeting strategies that direct nanoparticles to specific tissues, cells, or organs. This chapter explores the three primary targeting strategies: passive targeting, active targeting, and stimuli-responsive targeting. This chapter discuss the mechanisms, types of nanoparticles, design considerations, and clinical applications for each strategy, focusing on their use in cancer, neurological disorders, infectious diseases, and chronic conditions. The chapter also highlights recent advances, challenges in clinical translation, and the potential for personalized medicine using these systems.
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