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چکیده
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The important cause of infertility in males is torsion of the testicle in children. The medicinal plants are one of the approaches to improve the torsion adverse effects. This study aimed to investigate the effects of the hydroalcoholic extract of the Malva sylvestris on the spermatogenesis indices in mature mice following testicular torsion. In this study, 24 male mice were randomly divided into four groups (n=6) including the control group, where no intervention was performed, the torsion/detorsion group, in which the left testicle along with the spermatic cord was rotated 720 degrees counterclockwise for 1 hr, the group received M. sylvestri extract at a dose of 200 mg/kg and the treatment group received the extract through gavage for 35 days after torsion/detorsion. The comparison of spermatogenesis indices and histomorphometrical parameters in all groups indicated that seminiferous tubules diameter, germinal epithelium height, tubular differentiation index, repopulation index, and spermiation index were significantly decreased in torsion/detorsion group compared to the other groups. In torsion/detorsion + M. sylvestri g, all above-mentioned parameters were significantly increased and improved compared to the torsion/detorsion group, but had significant differences with control and M. sylvestri groups. The comparison of testicular capsule diameter showed that there were no significant differences between groups. Finally, it can be concluded that torsion and detorsion and complications caused by testicular ischemia/reperfusion cause damage and disorders in the male reproductive system, and it seems that M. sylvestirs hydroalcoholic extract due to the anti-oxidant and anti-inflammatory properties can improve the adverse effects of ischemia.
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