عنوان	Biological Activity of Mouse OX40L-Igg Purified With Two Novel Resins
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	OX40L-IgG, purification, MBI, MEP
چکیده	One of the important stimulating molecules for the function of T lymphocytes is tumor necrosis factor receptor OX40 (CD134), activated by its cognate ligand OX40L (CD134L, CD252). OX40L interactions have been proposed as a potential therapeutic target for treating infectious and non-infectious diseases. The main purpose of this study was to determine the potency of two novel resins MBI and MEP for the purification of OX40L-IgG fusion protein and the biological activities of this OX40L-IgG fusion protein. The biological activity of the OX40L-IgG purified by these resins compared with protein A sepharose resin. Mice treated with the same doses of the OX40L purified by the three resins showed a significant delay in tumor growth compared to the controls injected with PBS. Mice treated with the OX40L purified by MBI resin showed a significant delay in tumor cell (CT26) growth compared with mice injected with OX40L purified by other resins.
پژوهشگران	حسین رضوان (نفر اول)، سلمان علی (نفر دوم)، سحر هامون نورد (نفر سوم)، روبرت رییز (نفر چهارم)