مشخصات پژوهش

عنوان	Electrochemical detection of regorafenib using a graphite sheet electrode modified with nitrogen-doped reduced graphene oxide nanocomposite
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Electrochemical sensor; Regorafenib; Reduced graphene oxide; Graphite sheet electrode; Pharmaceutical analysis
چکیده	Regorafenib (RGF) is a multi-kinase inhibitor drug used for treating various cancers, posing challenges for detection in biological samples due to low solubility and stability. This paper presents a novel electrochemical sensor based on a monolith reduced graphene oxide (M-RGO) nanocomposite modified graphite sheet electrode. M-RGO was synthesized via a hydrothermal method and characterized extensively. The electrochemical performance was assessed using cyclic voltammetry and differential pulse voltammetry. The sensor demonstrated exceptional electrocatalytic activity for RGF oxidation, featuring two linear response ranges (31 nM to 600 nM and 600 nM to 920 nM) with a detection limit of 1.7 nM. The sensor exhibited good selectivity, stability, and reproducibility. Successful application in determining RGF in human serum and urine samples demonstrated the potential of M-RGO nanocomposite as a promising material for the development of electrochemical sensors for pharmaceutical analysis.
پژوهشگران	مریم حسین آبادی (نفر اول)، امیرعباس رفعتی (نفر دوم)، انسیه قاسمیان لمراسکی (نفر سوم)