مشخصات پژوهش

عنوان	Injectable, antibacterial, and oxygen-releasing chitosan-based hydrogel for multimodal healing of bacteria-infected wounds
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	antibacterial, oxygen-releasing, chitosan, hydrogel
چکیده	Bacterial infection is one of the main challenges of wound healing. It imposes financial and healthcare costs. The emergence of antibiotic-resistant bacteria has increased concerns about this challenge, and made finding alternative solutions a crucial aim. We created a new, antibacterial, multifunctional hydrogel with synergistic chemodynamic and photothermal features for wound-healing applications. We fabricated a chitosan (CT)-based hydrogel containing tannic acid (TA), Fe, and MnO2 nanosheets (CT–TA–Fe–MnO2) via a simple method and characterized it. The antibacterial features (resulting from the production of reactive oxygen species within bacterial cells) and healing ability (via anti-inflammatory and hemostatic features) of the hydrogel were confirmed in vitro. In vivo results revealed the effectiveness of the CT–TA–Fe–MnO2 hydrogel in decreasing the hemostatic time, improving anti-inflammatory effects, and promoting wound healing during 14 days by enhancing the deposition and maturation of collagen fibers without affecting the vital organs. The fabricated CT–TA–Fe–MnO2 hydrogel could be a promising candidate with antibacterial and anti-inflammatory activities suitable for wound-healing applications.
پژوهشگران	شایسته بوچانی (نفر اول)، عاطفه زارع پور (نفر دوم)، علی کلانتری حصاری (نفر سوم)، فخری حقی (نفر چهارم)، محمد علی شهبازی (نفر پنجم)، عزیز ملکی (نفر ششم به بعد)، علی ضرابی (نفر ششم به بعد)، سوفیا طاهری (نفر ششم به بعد)