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چکیده
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Multicomponent reaction (MCR) condensations involve three or more simple substrates is considered that approach close to the "ideal synthesis" due to atomic economy, and high bond forming efficiency. Compounds containing 1,3-amino oxygenated functional groups such as 1-amidoalkyl-2-naphthol derivatives frequently found in variety biologically active natural products and potent drugs such as a number of nucleoside antibiotics and HIV protease inhibitors [1]. Recently, nanoparticles were emerged in various fields including science, industry, pharmacy, medicine, and green chemistry [2]. Biochar is one of the novel nanoparticles, which is a stable carbon solid and used in various fields in past few years for science and engineering. Biochar is made via pyrolysis of biological source such as woody materials, agricultural wastes, green waste, animal manures and other waste products [3], therefore it is inexpensive and environmentally friendly. In this work Phosphoric acidactivated walnut shell biochar efficiently catalysis one-pot multi-component condensation of 2-naphthol with aromatic aldehydes and amide derivatives under solvent-free conditions to afford 1-amidoalkyl-2-naphthols in excellent yields and in very short reaction times
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