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چکیده
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Metal-Organic Frameworks (MOFs) are a bunch of new porous compounds that have expanded extensively over the last few years. These porous compounds are synthesized by bonding between metal ions and organic ligands [1]. Despite many years of synthesis and its various applications, magnetic particles retain their various applications and are expanding. Magnetite nanoparticles (Fe3O4) are used as suitable substrates for many catalysts [2]. Due to their magnetic properties, magnetic MOFs, using an external magnetic field, in addition to maintaining their previous properties, can be easily displaced and acquire a new feature [3]. Herein, a novel nano-magnetic Fe3O4 based metal-organic frameworks was synthesized and characterization by various analyzes. This is a synthesized catalyst for the synthesis of a wide range of fused nicotinonitrile derivatives compounds as suitable drug candidates through a four-component reaction during densification between aldehyde derivatives, acetophenone derivatives, 3-oxo-3-phenylpropanenitrile or 3-(4-chlorophenyl)-3-oxopropanenitrile and ammonium acetate through a vinylogous anomeric based oxidation in mild and solvent-free conditions at 110 °C were used. One of the most important features of the method used in this paper is the easy separation of the catalyst using an external magnetic field due to the magnetic nature of the synthesized catalyst.
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