مشخصات پژوهش

صفحه نخست /Curcuma reduces kidney and ...
عنوان Curcuma reduces kidney and liver damage induced by titanium dioxide nanoparticles in male Wistar rats
نوع پژوهش مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها Curcuma; Titanium dioxide nanoparticles Toxicity; Wistar rats
چکیده Objective: The current study was designed to investigate the protective effects of curcuma caplet against titanium dioxide nanoparticles (nTiO2)-induced damage in liver and kidney of male Wistar rats. Materials and methods: Thirty adult (7-8 week old) male rats (200 g) were randomly divided into 5 groups of 6 each. The first and second groups received olive oil and nTiO2 (300 mg/kg body weight) as control and nTiO2 groups, respectively. The third, fourth, and fifth groups received Curcuma at concentrations of 100, 200, and 300 mg/kg body weight in addition to 300 mg/kg body weight of nTiO2, respectively. The treatment was performed through gavage for 3 weeks. Rats' blood was examined for total antioxidant capacity (TAC), total oxidant status (TOS), and malondialdehyde (MDA) levels as well as antioxidant enzymes superoxide dismutase (SOD), and glutathione peroxidase (GPx), and activity of liver enzymes alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and renal factors (urea, uric acid, and creatinine). Histological analyses were also performed to estimate the extent of hepatic and renal injury. Results: nTiO2-induced liver and kidney damage by decreased serum SOD, GPx, and TAC (p<0.05). Fu +rthermore, nTiO2 increased serum MDA and TOS, and renal (Creatinine, Urea and Uric acid) and liver parameters (ALT, AST, ALP and LDH) (p<0.05). However, Curcuma treatment was able to moderate these changes dramatically (p<0.05). The results were confirmed by histopathological data. Conclusion: This study showed the antioxidant properties of curcuma against the side effects of nTiO2
پژوهشگران ماندانا شیردره (نفر اول)، فاطمه جباری (نفر دوم)، مریم صالح زاده (نفر سوم)، نسرین ضیا مجیدی (نفر چهارم)، علیرضا نوریان (نفر پنجم)، رقیه عباسعلی پور کبیره (نفر ششم به بعد)، شیرین حیدری ساسان (نفر ششم به بعد)، آذر قوامی شامخ (نفر ششم به بعد)، معصومه طاهری ازندریانی (نفر ششم به بعد)