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چکیده
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Background and aim: Omentin-1 is a newly discovered adipokine that plays an important role in the pathogenesis of insulin resistance and diabetes. We investigated the effect of 8- weeks aerobic exercise training on serum omentin-1, insulin resistance and lipid profile in smoker. Methods: Nineteen healthy men and twenty smoker men were randomly assigned into healthy control group (C), healthy exercise group (E), control smoker group (CS) and exercise smoker group (ES). Exercise groups participated in an 8-weeks aerobic exercise training program (three times a week, 45 min per session at 65%-80% of maximum heart rate). Serum omentin-1 and insulin levels were assessed by ELISA and HOMA-IR, glucose and lipid profile were measured before and after the intervention. Paired Sample t-test, oneway analysis of variance (ANOVA) and Tukey's post hoc test were used to analyze the data (p<0.05). Results: Aerobic exercise improved serum omentin-1 and high lipoprotein cholesterol (HDLC) in the exercise groups (p<0.05). Also, Exercise training reduced insulin, blood sugar, HOMA-IR, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels (p<0.05). Omentin-1 significantly correlated with insulin (r=-0.40, P=0.01), HOMA-IR (r=- 0.38, P=0.04), TG (r=-0.40, P=0.01), TC (r=-0.49, P=0.02), LDL-C (r=-0.70, P=0.02) and HDL-C (r=0.55, P=0.03). Conclusion: The findings suggest that aerobic exercise-induced changes in omentin-1 may be associated with the beneficial effects of exercise on reduced insulin and lipid profile in exercise trained smokers.
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