مشخصات پژوهش

عنوان	Synthesis and Evaluation of Antibacterial Activity of Chitosan- Encapsulated Enrofloxacin against Bacillus cereus
نوع پژوهش	مقاله ارائه شده کنفرانسی
کلیدواژه‌ها	Enrofloxacin, nano-encapsulation, antibacterial activity, Bacillus cereus
چکیده	Abstract Nanotechnology is an important part of technology which offers a great chance to develop new therapeutic agents for treatment of microbial infections in particular those caused by drug-resistant bacteria. The purpose of the present study was to synthesize enrofloxacinencapsulated polymeric nanoparticles and compare its antibacterial activity with pure enrofloxacin. Material and Methods: Enrofloxacin-encapsulated polymeric nanoparticles were prepared using Chitosan as a polymer and tripolyphosphate as cross linking agent. The obtained nanoparticles were characterized by dynamic light scattering (DLS) method. The antibacterial effects of the nanoparticles were evaluated using broth micro-dilution against B. cereus according to the CLSI manual 2012. Results: The drug-encapsulated nanoparticles had an average size of 39.84 nm. These nanoparticles indicated antibacterial activity against B. cereus. They also displayed stronger antibacterial activity than the nano-carrier alone (Chitosan) or pure enrofloxacin antibiotic. Minimum inhibitory concentration (MIC) of the nano-encapsulated Enrofloxacin molecules against the bacterial species was 60 ng/ml. Conclusion: The results suggest that enrofloxacin encapsulation in polymer nanoparticles has the potential to increase its antibacterial activity against B. cereus.
پژوهشگران	احمدرضا بخشی دزفولی (نفر اول)، عبدالمجید محمدزاده (نفر دوم)، پژمان محمودی کوهی (نفر سوم)، زهرا شریعتی نیا (نفر چهارم)