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چکیده
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Background: We investigated the effects of high-fat diet (HFD) consumption combined with diabetes induction, resistance exercise training (RET) and a de-training period on circulating irisin levels and selective metabolic parameters. Material and methods: Rats were assigned to four groups (n ¼ 8): healthy non-diabetic rats (NDC), non-diabetic rats that performed RET (NDR), sedentary HFD-fed/STZ-treated rats (HFD/STZ) and HFDfed/STZ-treated rats that performed RET (HFD/STZ þ RE). Results: HFD consumption reduced irisin level and Quicki (p < .01). After the 12-week period, levels of TC, TG, HOMA1-IR, HOMA2-IR and irisin were also lower in the HFD/STZ þ RE group compared to the HFD/STZ group. Body weight and HOMA1-IR showed a positive (r ¼ 0.558 and r ¼ 0.538) whereas TC and LDL-C had a negative correlation (r ¼ 0.461 and r ¼ 0.630) with irisin level (p < .05). Conclusions: Irisin level increased along with the progress of obesity and T2DM. It seems that RET can attenuate the increase of irisin in those conditions by improvement of glucose/lipid metabolic disorders.
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