|
چکیده
|
Background: Dianabol is an orally active, synthetic anabolic androgenic steroid. Low doses of these drugs are used to treat diseases such as anemia, poor growth in children and to reduce the spread of HIV. The main subject of this study is determination of adverse effects of dianabol in fertility rate of adult male mice. Materials and Methods: 18 adult male mice were divided into 3 groups of 6: Group 1: as control 0.2 ml distilled water were given daily through gavage. Group 2: received 5 mg/kg Dianabol daily by gavage. Group 3: were given 10 mg/kg of Dianabol daily by gavage. Treatment period was 6 weeks. At the end of the treatment, each mouse from each groups were coupled with three adult female mouse. Ten days after determining vaginal plaque, the animals were dissected and the number of embryos and corpora lutea were counted and fertility rate was examined. Results: Fertility examinations revealed that 5 mg/kg BW and 10 mg/kg BW made significant decrease in fertility rate compared with control group. Also, fertility rate of group 3 was declined in comparison with group 2. Moreover, evaluation of Arrested embryos showed that Dianabol in group 2 and 3 caused significant increase the arrested embryo in comparison with control group. Conclusion: Due to the results, it can be mentioned that dianabol considerably made dangerous effects on fertility specially increased arrested embryos. So, the athletes using dianabol must be careful in applying doses of this anabolic steroid.
|