مشخصات پژوهش

عنوان	Genome-wide association study to identify genomic regions affecting prolificacy in Lori-Bakhtiari sheep
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	GWAS, litter size, reproduction, luteinizing hormone, SNP
چکیده	Several causative mutations in candidate genes affecting prolificacy have been detected in various sheep breeds. A genome-wide association study was performed on estimated breeding values for litter size in Lori-Bakhtiari sheep. Prolific ewes with twinning records and others with only singleton records were genotyped using the medium-density Illumina Ovine SNP50 array. Four single nucleotide polymorphisms (SNPs) associated with litter size were identified on chromosomes 3, 6 and 22. The region on sheep chromosome 3 between 75 739 167 and 75 745 152 bp included two significant SNPs (s52383.1 and OAR3_80038014_X.1) in high linkage disequilibrium with each other. The region that surrounds these SNPs contains a novel putative candidate gene: luteinizing hormone/choriogonadotropin receptor (LHCGR), known to be involved in ovarian steroidogenesis and organism-specific biosystem pathways in sheep. Known prolificacy genes BMPR1B, BMP15 and GDF9 were not associated with litter size in Lori-Bakhtiari sheep, suggesting that other biological mechanisms could be responsible for the trait’s variation in this breed.
پژوهشگران	رامین عبدلی (نفر اول)، سید ضیاءالدین میرحسینی (نفر دوم)، نوید قوی حسین زاده (نفر سوم)، پویا زمانی (نفر چهارم)، سدریک گوندرو (نفر پنجم)