مشخصات پژوهش

عنوان	Pro-Inflammatory Gene Expression in Experimental Models Leishmania Wounds in BALB/C Mice
نوع پژوهش	مقاله ارائه شده کنفرانسی
کلیدواژه‌ها	Leishmania Wounds, Experimental Models, BALB/C Mice
چکیده	Abstract background: Leishmaniasis is an extensive lesion. Laboratory studies in this field could help improve diagnosis and treatment. This study focuses on pro-inflammatory gene expression in mice infected with Leishmania wound and infected mice without wound. Methods: The specific primers were designed for four pro-inflammatory genes including IL-1α, IL-1β, IL-12P35, IL-12P40, TNF- α and IFN- γ. Expression of these genes was analyzed using by RT-PCR in the wound and spleen in Leishmania infected with and without wound in BALB/c mice. Results: Pro-inflammatory genes were expressed in mice infected with the wound contains (TNF-α in spleen & TNF- α and IL-1β in wound) and in infected mice without wound contains (TNF-α in spleen & IL-1β in the injection position). Conclusion: Study on inflammatory gene expression in vitro model of leishmaniasis wounds can help improving this complication in vitro and vivo studies and is important for diagnostic strategies.
پژوهشگران	حسین رضوان (نفر اول)، سحر هامون نورد (نفر دوم)