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چکیده
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Electrochemical methods are more and more widely used for the study of electroactive compounds in pharmaceutical forms and physiological fluids due to their simple, rapid, and economical properties [1]. On the other hand, some urazole derivatives were found to be potent cytotoxic agents in murrain and human cancer cell lines and also reduce DNA synthesis considerably with moderate reduction in RNA synthesis [2]. With attention to these pharmaceutical properties of urazole derivatives, we anticipated that the synthesis of new nitrogen-containing compounds derivatives with the azide would be useful from the point of view of pharmaceutical properties. To synthesize new nitrogen-containing compounds derivatives we studied the electrochemical oxidation of hexamethylene-bis-urazole in buffer solutions and in the presence of a variety of nucleophile (Scheme 1)[3] .In the present paper, we describe the preparation of a new Nitrogen-containing compounds derivative using electrooxidation of hexamethylene-bis-urazole (1) in the presence of sodium azide as nucleophile.
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