مشخصات پژوهش

عنوان	Chelating effects of carnosine in ameliorating nickel-induced nephrotoxicity in rats
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	carnosine, nephroprotective, oxidative stress, kidney, lipid peroxidation
چکیده	The kidney is one of the main organs affected by nickel (Ni) toxicity. We investigated the protective effects of carnosine on Ni- induced oxidative stress in kidney of rats. Animals received NiSO4 (20 mg/kg/day i.g.) and/or carnosine (10 mg/kg/day, i.g.) for 21 days and then were evaluated for biochemical, molecular and histopathological alterations. Ni caused an increase in renal levels of malondialdehydes and a decrease in reduced glutathione, catalase and superoxide dismutase levels and total antioxidant capacity. Carnosine prevented the prooxidant and antioxidant imbalance induced by Ni. Ni-treated rats showed an increase in serum creatinine, urea and uric acid with a concomitant decrease in albumin. Ni markedly accumulated in kidney of Ni-exposed rats and its concentration was effectively reduced by carnosine treatment. Carnosine corrected the biochemical abnormalities and the elevated renal TNF-α and IL-6 levels in Ni group. It also attenuated Ni-induced abnormalities in renal architecture. Although carnosine showed antioxidant and anti-inflammatory effects in renal tissue of Ni-exposed rats, we cannot clearly attribute the protective effect of carnosine to its antioxidant and anti-inflammatory effects. Instead, the beneficial effect of carnosine observed in the current study can be due to the chelation between Ni and carnosine. Thus, carnosine may represent a therapeutic option to protect against Ni-induced nephrotoxicity that deserves consideration and further examination.
پژوهشگران	پریسا حسنین (نفر اول)، ژیلا فعله گری (نفر دوم)