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چکیده
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Abstract: Electrochemical methods are widely used for the synthesis of some new organic compounds due to their simple, rapid, and economical properties [1]. The interesting chemical properties of N-(2- hydroxyphenyl) acetamide NHA and its derivatives have inspired chemists to design and synthesize a variety of its derivatives [2]. On the other hand, diarylsulfones are important synthetic targets. They are useful in the practice of medicinal chemistry. The importance of these compounds has motivated us to synthesize a number of new diarylsulfones via electrochemical oxidation of NHA. Among the numerous methods to synthesize substituted NHA, Michael-addition reactions play an important role. In this context, as a part of a program to electrochemical synthesis of novel compounds based on the in situ generation of Michael acceptor [3] and containing of arylsulfinic acids moiety in structure. The electrochemical oxidation of NHA have been studied in various pH values in the presence of arylsulfinic acids as nucleophiles in aqueous solutions by using cyclic voltammetry and controlled-potential coulometry methods. The results indicate that the N-acetyl-o-benzoquinoneimine derived from oxidation of NHA participates in Michael type addition reaction with arylsulfinic acids to form the corresponding new sulfone derivatives of NHA. The present work has led to the development of a facile and environmentally friendly reagent-less electrochemical method for the synthesis of some new NHA derivatives in aqueous solutions with high atom economy.
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