|
چکیده
|
Endocrine glands have important effects in body function and metabolism. The thyroid disorders caused by different factors. Elettaria cardomomum is a herbal plant which widely used in traditional medicine. In this study the Eletaria cardomomum extract (ECE) effects on thyroid hormones and TSH in hypothyroid mice have been investigated.In this study 42 male mice, weighing 25-35 gr were randomly divided in 6 groups: control group (taking saline normal,0.5ml/day, i.p), levothyroxine treated group (15mg/kg/day, gavaged ), hypothyroid group (taking 0.1% propylthiouracil in drinking water for 2 weeks), and hypothyroid groups treated by ECE( 100, 200 and 400 mg/kg/day, i.p). After the end of experiments the mice were anesthetized and blood samples were collected from heart directly and T3 & T4 and TSH hormones were analyzed by ELISA method. All values are expressed as mean±SEM .The differences were compared using ANOVA followed by Tukey’s multiple comparison test and P<0.05 were considered statistically significant. Our results showed that the T3 &T4 plasma levels in hypothyroid animals treated by ECE had significant differences (P< 0.001) compared with control and hypothyroid alone and hypothyroid treated by levothyroxine groups. Our findings suggest that the ECE has stimulatory effect on thyroid gland function and raises plasma thyroid hormone levels.mice
|