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چکیده
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In recent years, multi-component reactions have awakened considerable interest in synthetic manners because of some advantages such as one-pot and simple route, high atom economy, large scope of structural variables, accessible of complex target molecules.1 Hydroxylamine- O-sulfonic acid (HOSA), is a dual role reagent that can be used both as nucleophile and electrophile in organic functional group transformations and heterocyclic chemistry according to the substrates used and reaction conditions.2-3 1,8-dioxo-octahydroxanthenes are a privileged scaffold of various heterocyclic compounds due to their numerous therapeutic and pharmaceutical activities. These versatile molecules have been used as antiinflammatory and antiplasmodial agent. In addition, these heterocyclic molecules have been widely used as dyes, and in pH-sensitive fluorescent materialsand laser technologies (Scheme 1)
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