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چکیده
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The etiology of Parkinson’s disease (PD) is incompletely understood. Some reports had mentioned iron concentration in midbrain of PD patients. Lactoferrin (LTF) is an 80 kDa iron-binding glycoprotein. Here, we have investigated LTF association with PD in Camelidae, human, bovine, horse, sheep, chicken, mouse, rat, dog and chimpanzee based on protein interaction network (PIN) and network analysis. According to STRING no edges were found between LTF with PD-associated proteins except of bovine and chicken. SNCA was related to bovine LTF and PD signaling pathways. In bovine, more than 85 proteins were associated to PD, that the most proportion of proteins were related to mitochondrion. The network density, network diameter and clustering coefficient of the PIN for bovine PD were 0.065, 9 and 0.381 respectively. We identified hub and high-degree proteins for NDUFB4 and NDUFAB1 respectively. Therefore it was concluded that bovine LTF is one of major protein in order initiating of signaling to PD-associated proteins.
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