مشخصات پژوهش

عنوان	Anti-nociceptive and Anti-hyperglycemic Effects of Melissa officinalis Essential Oil in an Experimental Model of Diabetes
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	Hyperalgesia, Diabetes, Melissa officinalis, Rats
چکیده	Objective: The efficacy of oral administration of Melissa officinalis essential oil (MOEO) on hyperalgesia was investigated using the formalin test in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Animals were divided into control, MOEO-treated control (0.01, 0.02 and 0.04 mg/day), diabetic and MOEO-treated diabetic (0.01, 0.02 and 0.04 mg/day) groups. Nociceptive testing was performed on male adult Wistar rats 4 weeks after the onset of hyperglycemia. At the end of the experiment, all rats were weighed and plasma glucose measurements were performed. Results: Diabetes was associated with significant hyperalgesia during both phases of the formalin test. MOEO (0.04 mg/day) completely reversed hyperalgesia in diabetic rats. MOEO (0.02 and 0.04 mg/day) caused less intensive nociceptive behaviors during both phases of the test in control rats. MOEO at both high doses restored euglycmeia and reduced body weight of treated diabetic animals compared to untreated diabetic animals. The 0.01 mg dose of MOEO did not alter pain responses in control or diabetic groups compared to their respective controls. Conclusions: This study shows that chronic administration of MOEO displays efficacy in an experimental model of diabetic hyperalgesia. MOEO may therefore show promise as a treatment for painful diabetic neuropathy.
پژوهشگران	پریسا حسنین (نفر اول)، حسن ریاحی (نفر دوم)