مشخصات پژوهش

عنوان	Quorum-sensing inhibitors for control of Staphylococcus aureus biofilm
نوع پژوهش	مقاله ارائه شده کنفرانسی
کلیدواژه‌ها	Staphylococcus aureus, quorum-sensing inhibitors, biofilm
چکیده	Background and Aim:Staphylococcus aureus is responsible for fatal diseases as a result of the expression of multiple virulence factors, and this organism is one of the most important biofilm-forming pathogens that cause complications ranging infections. Biofilms can be defined as structured aggregation of surface-attached microorganisms kept by an extracellular matrix. Increased resistances of bacteria to antimicrobial agent occur due to dormant phenotype in biofilm phase. The challenge in treating biofilm-associated infections caused by S. aureus is one of the most problems in veterinary and medicine science. Quorum-sensing is based on the synthesis and secretion of small hormone-like molecules (autoinducers). These molecules can bind to cognate receptors and contribute to biofilm formation. The purpose of this article is introducing quorum-sensing inhibitors (QSI) as novel strategies to control biofilm formation by S. aureus. Methods:Two phenotypic tests, including growth on microtitre plates and Congo red agar are used for detection of biofilm formation. Results:QSI consist of synthetic and natural agents. Hammelitannin (HAM) is a non-peptideanalog of the quorum-sensing inhibitor RNAIII-inhibitingpeptide (RIP). HAM decreases both in vitro and in vivo S. aureus attachment. Polymethylmethacrylate(PMMA) was shown to be able to prevent biofilm formation in orthopedic infections caused by methicillin-resistant S. aureus. Poly-trimethylene carbonate (PTMC) is able to inhibit biofilm formation of S. aureus intreatment of osteomyelitis. Antibody against quorum-sensing peptide AP4 is one of the best candidate to suppress S. aureus pathogenicity in mouse abscess infection model. Silver nanoparticles have been shown to enhance quorum-quenching activity and prevention of biofilm formation. Conclusion: A mechanism of action of QSI is repression of signal generation, blockage of signal receptors, and disruption of QS signals. As for the importance of these molecules in the inh
پژوهشگران	عبدالمجید محمدزاده (نفر اول)، آرام شریفی (نفر دوم)، پژمان محمودی کوهی (نفر سوم)، بهروز عباس آبادی (نفر چهارم)، رضا حکیمی النی (نفر پنجم)