مشخصات پژوهش

عنوان	GABAA receptors are involved in the analgesic effects of morphine microinjected into the central nucleus of the amygdala
نوع پژوهش	مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها	amygdala, antinociception, bicuculline, muscimol, opioid
چکیده	1.The central nucleus of the amygdala (CeA) has an important role in pain perception and analgesia. Opioid and GABAA receptors which both involved in pain modulation are found in high concentration in the CeA. So the present study was designed to examine interaction of opioidergicandGABAergic systems in the CeA on modulation of acute thermal pain. 2. Different doses of morphine (25, 50 and 100 µg/rat) alone or with 5 min pretreatment of a selective GABAA receptor agonist, muscimol, (60 ng/ rat) and a selective GABAA receptor antagonist, bicuculline, (50 ng/rat) were injected bilaterally into the CeA of each rat.Tail-flick latencies(TFLs) were measured every 5 min for 60 min. 3.Microinjection of morphine in different doses into the CeA increased significantly TFL in a dose-dependent fashion. Microinjection of bicuculline and muscimol in combination with morphine into the CeA respectively increased and decreased TFL in a dose-dependent fashion. 4. According to the results, it seems that morphine in the CeA, facilitates the function of pain descending inhibitory systems by interaction with the activity of local GABAA receptors.
پژوهشگران	مینا رشوند (نفر اول)، علی خواجوی (نفر دوم)، محسن پرویز (نفر سوم)، پریسا حسنین (نفر چهارم)، منصور کشاورز (نفر پنجم)