مشخصات پژوهش

صفحه نخست /Ameliorative effect of ...
عنوان Ameliorative effect of Matricaria chamomilla.L on paraquat: Induced oxidative damage in lung rats
نوع پژوهش مقاله چاپ‌شده در مجلات علمی
کلیدواژه‌ها Lung, Matricaria chamomilla. L , Oxidative stress, paraquat, Rat
چکیده Background: Herbal medicines have been long used for antioxidant properties. The purpose of this study was to investigate the effect of hydroalcholic extract Matricaria chamomilla. L (M. chamomilla) against Paraquat (PQ) induced pulmonary injury in association with its antioxidant activity. Materials and Methods: Effective doses of PQ (5 mg/kg/day) and M. chamomilla (50 mg/kg/day) were administered alone or in combination for 7 days. At the end of the experiment, lung tissue of the animals was separated. The activity of enzymatic scavengers such as glutathione peroxidase (GPx) and superoxide dismutase (SOD), lipid peroxidation (LPO) and total antioxidant power (TAP) were measured. Results: In these samples, the LPO, SOD, and GPx were higher in the PQ group as compared with controls. M. chamomilla extract ameliorated LPO, SOD, GPx and increased TAP in plasma and lung tissue of PQ induced changes. Co administration of PQ with M. chamomilla improved LPO and SOD, and GPx. Conclusion: M. chamomilla as natural antioxidant may be considered beneficial for the protection oxidative lung injury in PQ poisoning.
پژوهشگران اکرم رنجبر (نفر اول)، فریبا محسن زاده (نفر دوم)، عبدالکریم چهرگانی راد (نفر سوم)، فرزاد خواجوی (نفر چهارم)، سید مصطفی حسینی ذیجود (نفر پنجم)، حسن قاسمی (نفر ششم به بعد)