Background: Heavy metal contamination of food products that caused by industrial activities is one of the most important risks that treats natural ecosystems and human. Edible fungi as a worth herbal origin full protein food is favored by consumers worldwide. The present study determined lead and cadmium concentrations in offered edible button-like fungi in Hamedan. Materials & Method: 60 samples of edible button-like fungi were collected from the local super markets in Hamedan, Iran. Humidity percent of samples was measured and then withe ash of samples obtained by electrical furace in 550 C°. Obtained ash dissolved by 1 ml concentrated nitric acid. Flaming atomic absorption used for determination of lead and cadmium concentrations. Results: The average of lead and cadmium concentrations in samples was 0.7 ± 0.08 and 0.01 ± 0.008 mg/kg, respectively. The detected contents of lead and cadmium elements were lower than standard limits of WHO in edible fungi. Conclusion: It is concluded that lead and cadmium concentrations in offered edible button-like fungi in Hamedan aren’t worrisome