Background and Objectives : One of the mostimportant zoonosis, cystic Echinococcosis is endemic in some parts of the Middle East, such as Iran. There are some studies on the prevalence of this infection in animal and human in Iran. This cross-sectional study aimed to evaluate the prevalence of CE in human of Hamedan since 2013 to 2019. Method: In this cross-sectional study, the hamedan health center records of all hydatidosis-affected patients admitted in three teaching hospitals of Hamedan Province between 2013-2019 were reviewed. Hydatidosis-relevant demographic characteristics, clinical findings, age, sex, contact with dog, Consume contaminated vegetables data were collected. Also, the numbers of infected slaughtered animals in these years, were recorded . The descriptive statistical analysis was performed by SPSS soft ware. Results: Totally,98 patients with the mean age of 10-60 yr were admitted with cystic Echinococcosis (CE) diagnosis. Moreover, the highest and the lowest prevalence of CE cases were in age ranges of more than 50 (31.63%) and less than 10 (5.1%) yr, respectively. Male and female infected were 51.02 % and 48.97% . Majority of the cases were urban residents (53.06 %) and 41.83% patients had close contact with dog and Consume contaminated vegetables, Simultaneously, but 58.16% only Consumed contaminated vegetables. The highest prevalence of CE cases in women and men occurred in 2013 ( 35.41%) and 2013 , 2017 ( 34%) , respectively . The affected organ was liver in 59.2% patients. Discussion and Conclusion: According to high prevalence of cystic Echinococcosis and its financial burden, control programs should be essential for decreasing the burden of disease in this region.