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Abstract
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Introduction: Alzheimer's disease is the most common cause of dementia in the world, but strategies to slow or prevent its clinical progression have remained largely elusive until recently; therefore, this research was conducted with the aim of investigating the effect of exercise and turmeric on Alzheimer's disease. Method: For this purpose, in this study, 42 Alzheimer's patients were selected and divided into three groups: exercise, turmeric, and control; Subjects in the exercise group did aerobic exercise for 12 weeks, 3 sessions per week, and the turmeric group received 800 mg of turmeric powder in capsule form daily for 12 weeks (approximately 100 mg of curcumin daily). Participants completed the Pittsburgh Sleep Quality Index (PQSI), Neuropsychiatric Inventory-Questionnaire (NPI-Q), Quality of Life-Alzheimer’s Disease (QOL-AD) at the beginning and after the end of the intervention. Then the data were analyzed by Friedman and ANCOVA test in SPSS version 21 (P<0.05). Results: The findings showed that the scores of the PQSI improved significantly only in the group that exercised, but the values of the NPI-Q and the QOL-AD in both the exercise and turmeric groups showed a significant improvement compared to the control group. Conclusion: gave Advances in understanding the etiology of the disease require a multiple-sitetargeted therapy, and the combination of curcuminoids from turmeric with exercise, each of which has different merits, makes this combination even more promising in combating the challenging disease.
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