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Title
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Biological Activity of Mouse OX40L-Igg Purified With Two Novel Resins
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Type
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JournalPaper
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Keywords
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OX40L-IgG, purification, MBI, MEP
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Abstract
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One of the important stimulating molecules for the function of T lymphocytes is tumor necrosis factor receptor OX40 (CD134), activated by its cognate ligand OX40L (CD134L, CD252). OX40L interactions have been proposed as a potential therapeutic target for treating infectious and non-infectious diseases. The main purpose of this study was to determine the potency of two novel resins MBI and MEP for the purification of OX40L-IgG fusion protein and the biological activities of this OX40L-IgG fusion protein. The biological activity of the OX40L-IgG purified by these resins compared with protein A sepharose resin. Mice treated with the same doses of the OX40L purified by the three resins showed a significant delay in tumor growth compared to the controls injected with PBS. Mice treated with the OX40L purified by MBI resin showed a significant delay in tumor cell (CT26) growth compared with mice injected with OX40L purified by other resins.
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Researchers
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Robert Rees (Fourth Researcher), sahar hamoon navard (Third Researcher), selman A Ali (Second Researcher), Hossein Rezvan (First Researcher)
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