|
Abstract
|
Preface Owing to the widespread presence of amines in pharmaceuticals, polymers, natural products, organic materials, and catalysts, studying, understanding, and predicting the structure, and exploiting or minimizing the side products of amine synthesis processes have received great attention and importance in recent years. As such, the identification and development of efficient, robust, and practical methods for their synthesis is of significant importance in both industry and academia. While many chemical methods exist for N-arylation, the exploration of new strategies that offer concise and re- giospecific access remains a topic of considerable interest. This book provides a concise report of various protocols for C–N bond formation. The book is well structured, with topics which are logically divided into five chapters. This book is an invaluable reference for undergraduates, post- graduates, and chemical researchers working in either industry or university. The first chapter describes the historical background of the synthetic methods and properties of amines. In the second chapter, the discovery and development of N-alkylation and methylation of amines are reviewed. A concise overview of modern transition- metal-catalyzed approaches for the synthesis of alkyl amines and their functionalization is provided in this chapter. This chapter contains selected examples of amine bond-forming reactions including (a) hydroamination and hydroaminoalkylation, (b) transition-metal-catalyzed C(sp3 )–H functionalization, (c) transition-metal-catalyzed visible-light-mediated light photoredox catalysis, and (d) borrowing hydrogen. The third chapter focuses on the recent developments in the synthesis of primary anilines via the reaction of arylating reagents (such as aryl halides, phenylboronic acid, benzene, phenol, and aryl metals) with nitrogen sources. Methods and Strategies for C–N Bond Formation Reactions By Zahra Taherinia, Maryam Hajjami and Arash Ghorbani-Choghamarani
|