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Title
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Electrochemical study of 2-amino-5-mercapto- 1,3,4-thiadiazole in the absence and presence of pbenzoquinone: an efficient strategy for the electrosynthesis of new 1,3,4-thiadiazole derivatives
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Type
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JournalPaper
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Keywords
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Electrochemical study of 2-amino-5-mercapto- 1,3,4-thiadiazole in the absence and presence of pbenzoquinone: an efficient strategy for the electrosynthesis of new 1,3,4-thiadiazole derivatives
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Abstract
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In this study, first, the electrochemical behavior of 2-amino-5-mercapto-1,3,4-thiadiazole (AMT) was fully investigated in the absence and presence of electrochemically generated p-benzoquinone (p-BQ, which is the oxidized form of hydroquinone), as an electrophile, via cyclic voltammetry (CV) at a glassy carbon electrode (GCE) and in an acetic acid buffer (0.2 M)/ethanol solution mixture. Then, an E–pH diagram was proposed for different structures of AMT at various pH values. The obtained voltammograms also exhibited an “electron transfer + chemical reaction” (EC) mechanism. Besides the voltammetric exploration, electrosynthesis of new 1,3,4-thiadiazole derivatives was conducted by constant current electrolysis (CCE) as a facile and cost-effective method for the formation of S–S and S–C bonds. Finally, the biological activity of products was also analyzed via an in silico method.
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Researchers
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. . (Third Researcher), Sadegh Khazalpour (Second Researcher), hossein masoumi (First Researcher)
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