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Abstract
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Substituted pyridines are common in many biologically active compounds, among them 3-cyano-2-hydroxypyridines have been an essential part of molecular structures for the design and construction of a variety of biologically active compounds [1]. Recently multicomponent reactions (MCRs) has received great attention from researchers for the synthesis of new heterocyclic compounds due to the wide range of their potential biological and pharmaceutical activities and industrial applications [2]. On the other hand, magnetic nanocatalysts are easy to separate from reaction media, thus have been used for various purposes [3]. Herein, we represent the synthesis of novel pyridines incorporated with 1,2,3-triazole via a green one-pot four-component reaction of arylaldehydes, ethyl cyanoacetate, 1-(5-methyl-1-(4-nitrophenyl)-4,5-dihydro-1H-1,2,3-triazole-4-yl)ethenone and ammonium acetate using a recyclable magnetic nano-sized catalyst as a highly efficient catalyst under solvent-free and thermal conditions with high yield (Scheme 1).
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