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Title
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Vivid catalytic application of magnetic nanoparticles (MNPs) at the synthesis of linked imidazo[1,2-a]pyridine ring systems
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Type
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Presentation
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Keywords
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Imidazo[1,2-a]pyridine, Magnetic nanoparticles, Multicomponent reaction
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Abstract
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Magnetic nanoparticles have gained a great deal of attention from both academic and industrial point of view, owing to their unique properties including high surface area, and superparamagnetism, which enable them to be suitable for modification with many compounds and employing them as a catalyst in organic reactions [1]. Carbon-carbon and carbon-heteroatom bond-forming reactions are at the center of organic synthesis. Multicomponent cascade reactions have become a powerful tool in modern organic synthesis for the drug discovery processes [2,3]. Bridgehead nitrogen heterocycles are of interest because they constitute an important class of natural and unnatural products and many of them are useful as biological compounds [4]. Saturated and partially saturated imidazo[1,2-a]pyridine ring systems exhibit pharmacological properties such as antiviral [5], antimalarial [6] and antiulcer activities [7]. In this research, we have synthesis and take application of surface-modified magnetite nanoparticles as magnetically recoverable catalyst in the prepration of some novel imidazo[1,2-a]pyridine ring systems under mild and solvent-free condition.
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Researchers
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Meysam Yarie (Fourth Researcher), MORTEZA TORABI (Third Researcher), ma z (Second Researcher), Amirmahdi Tavassoli (First Researcher)
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