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Abstract
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Metal-organic frameworks (MOFs) are a group of porous materials that are a new class of new generation nanoreactors consisting of metal and organic compounds as ligands. MOFs have distinctive features such as large surface area, adjustable pore size, very diverse structure, and adjustable chemistry due to their two-dimensional and three-dimensional porous structure [1-2]. This unique structure of MOFs has given them applications in various fields such as magnetic resonance imaging (MRI), catalyst, biotechnology, gas separation and storage, drug absorption, purification and drug delivery [3]. Hydrogen bond donor catalysis (HBD) is known as an effective method for the synthesis of highly valuable intermediates for the pharmaceutical and agricultural industries, as HBD catalysts are able to selectively bind and activate active substrates during the reaction process through hydrogen bonding [4]. The integration of metal-organic frameworks and compounds that play the role of HBD catalysts can be very attractive. In this research, a metal-organic frameworks (MOFs) was designed based on titanium. Then, using the post-modification method, we created the composition of urea in its structure. The Ti-MOF-UR was used as a as hydrogen bond catalyst in the synthesis of pyrazolo[3,4-b]quinoline (Scheme 1). The newly prepared catalyst showed a very good activity. The most important features of this work are the green and mild reaction conditions, short reaction time as well as high efficiency of products. Pyrazolo[3,4-b]quinoline have been used as a drug candidate for antimicrobial, cancer, malaria, anticonvulsant, antifungal, HIV, anti-tumor, antioxidant, antihypertension and urinary incontinence treatment [5].
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