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Title
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Protective Effects of High-Intensity Interval Training Exercise Separately and in Interaction with Ecdysterone against Amyloid BetaInduced Rat Model of Alzheimer’s Disease: A Behavioral, Biochemic
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Type
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Presentation
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Keywords
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β-amyloid (Aβ), Alzheimer’s disease (AD), Ecdysterone, High Intensity Interval Training (HIIT), learning, oxidative stress
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Abstract
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Background and Aim: Oxidative stress and neuronal death are the major reasons for the progression of β-amyloid (Aβ) deposition in Alzheimer’s disease (AD)-associated motor and cognitive deficits. Ecdysterone (Ecdy) is one of the components of phytoestrogen that is an insect hormone and provides regulating with their molting, development and reproduction also, it is widespread among a huge number of plants with pharmacological impacts such as anti-oxidation profits and promoting learning and memory. High-Intensity Interval training (HIIT) is a form of interval training that regulates hippocampal oxidative stress and reducing learning decline. The purpose of this study was to investigate the separate and the interactive effects of Ecdy supplementation and HIIT against AD-associated behavioral deficits, hippocampal oxidative status and histological changes in an amyloid beta (Aβ)-induced rat model of AD. Methods: Seventy-two adult male Wistar rats were randomly divided into nine Groups and 10 days after Aβ-injection, treated with eight consecutive weeks HIIT exercise and Ecdy (10 mg/kg/day; P.O.). Then, after treatment course, behavioral functions measured by common behavioral tests. Subsequently, brains extracted and stress oxidative factors and histological changes evaluated. Results: The results of behavioral tests indicated that Aβ injection damaged learning and spatial memory in Morris water maze test and reduced passive avoidance learning in shuttle box test. These behavioral impairments were accompanied by decrease of hippocampal antioxidant enzymes (Superoxide Dismutase content and Catalase level), and neuronal loss in the cerebral cortex and hippocampus in Nissl staining. Although, HIIT and Ecdy separately promoted learning and memory, increased hippocampal antioxidant enzymes content, and prevented neuronal loss in the rats treated with A beta, their combination resulted in a more powerful and effective improvement in mentioned Aβ-induced deficits. Conclusion
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Researchers
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(Third Researcher), alireza Komaki (Second Researcher), (First Researcher), Hesam Parsa (Fourth Researcher)
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