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Abstract
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Background: Adipocytokines, which are secreted by the adipose tissue, contribute to the pathogenesis of obesityrelated complications. To evaluate this assumption, we investigated the efects of aerobic exercise training (AET), resistance exercise training (RET), and 4 weeks of de-training on serum leptin and TNF-α levels in diabetic rats. Method: 36 Wistar rats were divided into normal diet (ND) (control, RET, AET) and high-fat diet (HFD)+STZ (control, RET, AET) groups. Serum insulin, leptin, and TNF-α levels were assessed by commercial ELISA kits. Also fasting blood glucose (FBG), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) levels were measured by the colorimetric kits. Results: Diabetes induction increased body weight (BW) and FBG, and decreased insulin compared to the ND rats’ groups (p<0.001). 12-weeks of AET and RET programs in the trained diabetic rats led to a decrease in TG, LDL-C, leptin, TNF-α, and FBG, and an increase in insulin compared to the HFD+STZ-C group (p<0.001). Besides, there was no diference between AET and RET in improving the variables studied (p>0.05). Also, de-training led to increased BW, TG, leptin, and TNF-α compared to the end of the exercise training (p<0.05). The correlation between the variables studied was established at diferent stages of the study (p<0.05), and only BW was not correlated with insulin during exercise training and de-training (p>0.05). Conclusion: These fndings indicate that both AET and RET are useful in reducing levels of serum adipocytokines (TNF-α, leptin) in diabetic and non-diabetic rats. At the same time, 4 weeks of de-training was sufcient to lose the metabolic adaptations.
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