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Title
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Glucose cross-linked temperature-responsive gelatine hydrogel for targeted delivery of curcumin anticancer drug
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Type
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Presentation
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Keywords
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-
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Abstract
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In this work, a temperature-responsive hydrogel was synthesized based on a glucose-cross-linked gelatine. Polydopamine nanoparticles were incorporated into the hydrogel as NIR light chromophores. pH-responsive chitosan coated curcumin anticancer drug nanocapsules were also incorporated in the hydrogel to enable dual-stimuli sensitive delivery. The results showed that the drug release was higher at acidic pH values. However, it was not considerable at 37 ᵒC. A 940 nm NIR laser was used to heat-up the hydrogel. The results showed that under laser irradiation the drug release was significant at acidic pH values
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Researchers
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Mazaher Ahmadi (Fourth Researcher), Abbas Afkhami (Third Researcher), Tayyebeh Madrakian (Second Researcher), Leila Gholami (Fifth Researcher), (First Researcher)
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