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Title
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Electrochemical behavior and oxidation mechanism of hydroxychloroquine as a drug treating COVID-19 in aqueous solutions
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Type
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Presentation
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Keywords
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COVID-19, Hydroxychloroquine, Electrochemical behavior, Oxidation mechanism.
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Abstract
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In this study, the electrochemical behavior and oxidation mechanism of HCQ as a drug treating COVID-19 in aqueous solutions was investigated using cyclic voltammetry on the glassy carbon electrode. The effects of pH and potential scan rate on peak potential and peak current of oxidation produced from the oxidation of HCQ were studied. Cyclic voltammograms of HCQ at various pH values indicated that the potential of anodic peak (EpA1) depends on the pH of the solution and shift to the negative values by increasing pH. This is due to the participation of proton(s) in the oxidation of HCQ to the form of HCQred. The results for the investigation of the effect of potential sweep rate on the anodic peak current of HCQ on the GCE by cyclic voltammetry indicated that the anodic peak current is almost equal with the square root of scan rate (v1/2), this confirms that considering the anodic peak current and based on the Randles– Sevcik equation, the absorptive-controlled process for electrooxidation of HCQ on the surface of GCE. According to the acquired potential-pH diagram and the oxidation of the HCQ, a reaction mechanism involving 1-electron/2-proton oxidation of HCQ was proposed. Finally, according to the results, our prediction for the oxidation of HCQ is through the CE mechanism.
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Researchers
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Davood Nematollahi (Third Researcher), amin ansari (Second Researcher), (First Researcher)
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