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Title
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Synthesis of 5,8-Diaryl-5,7,8,9-Tetrahydropyrimido[5,4-e]Tetrazolo[1,5-a]Pyrimidin-6(4H)-One Derivatives Catalyzed by MNPs@SiO 2 -Pr-AP as a New Efficient Reusable Nanomagnetic Catalyst
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Type
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JournalPaper
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Keywords
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Multi-component reactions; Pyrimidine derivatives; Aromatic aldehydes; Magnetic nano particle; Nano catalyst.
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Abstract
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Some novel 5,8-diaryl-5,7,8,9-tetrahydropyrimido[5,4-e]tetrazolo[1,5-a]pyrimidin-6(4H)-one derivatives are prepared via one-pot reaction of aromatic aldehydes, 2-aminotetrazole and cyanoacetamide using two different types of catalytic systems including nano-magnetic catalyst supported with functionalized 4-amino-pyridine silica (MNPs@SiO2-Pr-AP) and NEt3.The highlighting points of using MNPs@SiO2-Pr-AP are easy purification, reusability of the catalyst, good yields of products with short time reactions compared with NEt3. Also the DFT calculations showed that a trans-like isomer is more stable than other possible isomers/conformers. The experimental data are also consistent with a pure compound rather than a mixture of isomers.
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Researchers
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(Fourth Researcher), Zahra Toghraei-SEMIROMI (Third Researcher), Ramin Ghorbani-Vaghei (Second Researcher), (First Researcher)
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