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Title
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CaTiO3/α-TCP coatings on CP-Ti prepared via electrospinning and pulsed laser treatment for in-vitro bone tissue engineering
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Type
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JournalPaper
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Keywords
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Bone regeneration CaTiO3 CP-Ti Electrospinning Laser modification
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Abstract
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In this study, the in-vitro bone regeneration ability of commercial pure titanium (CP-Ti) surface modified via electrospun polyvinylidene/hydroxyapatite (PVP/HA) masking and subsequent Nd-YAG pulsed laser treatment was investigated. The ratio of HA to PVP played a significant role in achieving a perfect homogenous mask on the CP-Ti. In the laser treatment process, the parameter of area scanning speed (ASS) had an important influence on the final surface morphology. A favorable range was defined for this parameter where these two conditions were satisfied: no PVP remaining and no severe substrate melting. Within a favorable range of ASS, as decreasing ASS exchanged the surface structure from detached particles to a pattern-like network. The calcium titanate CaTiO3 (CTO) and α-tricalcium phosphate (α-TCP) were formed as the main components on the CP-Ti surface. The coating had an adequate adhesion to the CP-Ti surface. Furthermore, a surface with a water affinity between hydrophilic and hydrophobic was obtained. The in-vitro bioactivity test revealed that the surface modification enhanced the bone-like apatite formation. The cytocompatibility assays confirmed that the cell attachment and spreading of the osteosarcoma-like cells (MG63) were improved by the surface treatment. The development of surface modification techniques opens new avenues in bone tissue engineering applications.
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Researchers
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Maryam Mohammadi (Fourth Researcher), mohsen sheikhi (Third Researcher), Hamid Esfahani (Second Researcher), (First Researcher)
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