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Title
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Synthesis and application of melamine-based nano catalyst with phosphonic acid tags in the synthesis of (3´-indolyl)pyrazolo[3,4-b]pyridines via vinylogous anomeric based oxidation
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Type
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JournalPaper
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Keywords
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Cooperative vinylogous anomeric based oxidation Acid catalysis Nanostructured catalyst (3´-Indolyl)pyrazolo[3,4-b]pyridines Multicomponent reaction
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Abstract
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A novel nanostructured melamine-based organo solid acid with phosphorus acid tags was designed, synthesized and fully characterized. The catalytic activity of the resulted melamine hexakis(methylene)hexakis(phosphonic acid) (MHMHPA) as a heterogeneous catalyst was also investigated via an one-pot reaction between cyanoacetylindole, 3-methyl-1-phenyl-1H-pyrazol-5-amine, and an aromatic aldehyde. (3´-Indolyl)pyrazolo[3,4-b] pyridines were produced in good yields under refluxing ethanol. The solid catalyst can be recovered easily and reused without a significant loss of its catalytic activity.
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Researchers
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Ardeshir Khazaei (Third Researcher), Abbas Khoshnood (Not In First Six Researchers), Diego Alonso (Not In First Six Researchers), Yanlong Gu (Fifth Researcher), (Fourth Researcher), ma z (Second Researcher), javad afsar (First Researcher)
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