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Title
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Application of novel Cu-based metal organic frameworks (MOFs): Application in synthesis of 7-amino-2-(1H-indol-3-yl)-5-phenylpyrazolo[1,5-a]pyrimidine-6-carbonitrile
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Type
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Presentation
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Keywords
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Fused heterocyclic, Multicomponent reactions, Metal organic frameworks (MOFs), Solvent free.
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Abstract
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Pyrazolopyrimidines are fused heterocyclic ring systems which structurally can consider as bioisosteres of adenine, which is fundamental for every aspect of cell life. Pyrazolo[3,4-d]pyrimidines derivatives have been explored for their inhibitory activity towards various protein kinase enzymes and their role as anticancer agents [1]. On the other hand, metal organic frameworks (MOFs) as eco-friendly and green catalysts play an important role in the chemical processes. Easy recovery and reusability of these catalysts have led to their extensive use in the synthesis of a wide range of compounds [2-3]. Metal-organic frameworks (MOFs) based on the type of their ligands and functional groups on their surface exhibit different properties. Their functional groups may initially be present in the organic ligand structure or after synthesizing MOFs to create functional groups within the structure. Herein, we wish to report a clean method for synthesis of pyrazolopyrimidine derivatives under solvent free condition in the presence of MOF-Cu (10 mg) as an efficient nano-catalyst
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Researchers
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ma z (Fifth Researcher), Hassan Sepehrmansourie (Fourth Researcher), (Third Researcher), (Second Researcher), (First Researcher)
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