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Title
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Study of telomerase reverse transcriptase and uterine-ovarian-specific genes expression in the endometrial tissue of ovariectomized female Sprague-Dawley rats
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Type
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JournalPaper
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Keywords
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Tamoxifen, TERT, SLN, UO-44
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Abstract
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Background: An in vivo study was carried out to study of telomerase reverse transcriptase and Uterine-Ovarian-specific genes expression in the endometrial tissue of ovariectomized female Sprague-Dawley rats. Material and methods: Twenty-four female Sprague-Dawley rats divided into 4 groups of six rats. The first and second groups were ovariectomized and given tamoxifen and tamoxifen-loaded SLN respectively for six days continuously. Group 3 served as the untreated ovariectomized control group and group 4 was made up of un-treated normal healthy rats. At the end of the study, the rats were sacrificed and study of the genes expression and serum zinc and copper were carried out. Results: The results showed that the expression of TERT in the group treated with tamoxifen, and tamoxifen-loaded solid lipid nanoparticles, significantly decreased (p b 0.001) compared with ovariectomized control group. The results also revealed that the treatment with tamoxifen-loaded solid lipid nanoparticles increased expression of UO-44 gene compared to ovariectomized control group, while there was no difference between tamoxifen treated and control group. Conclusions: Encapsulation of tamoxifen in solid lipid nanoparticles increased its targeting efficiency and improved the impact of the drug on the serum levels of some trace elements.
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Researchers
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Alireza Nourian (Not In First Six Researchers), Mahnaz Ashrafi (Not In First Six Researchers), Reza Aflatoonian (Fifth Researcher), Roghiyeh Abbasalipourkabir (Fourth Researcher), Saman javid (Third Researcher), Nasrin ziya majidi (Second Researcher), Shadi Foroughi (First Researcher)
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