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Abstract
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Nowadays, due to the biological importance of pyridine derivatives, these versatile molecules have found several applications in both medicinal and industrial fields. Highly substituted pyridines are applied as nonlinear optical materials, electrical materials, chelating agents and fluorescent liquid crystals. Also, these heterocyclic structures represent varied pharmaceutical activities. Pyridine derivatives can be found in several biologically active compounds, like antitumoral 2-amino-4-aryl-6-dialkylamino-3,5-dicyanopyridines and antiproliferative 2,6- dibenzylamino-3,5-dicyanopyridines [1-3]. In this study, a green protocol has been reported for the synthesis of highly substituted pyridine derivatives using magnetic nano particles with acidic tags as recoverable catalyst under solvent free conditions via a vinylogous anomeric based oxidation mechanism. The reported method represents varied merits such as clean reaction profile, short reaction time, high to excellent yields and simple workup procedure.
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