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Abstract
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M efenamic acid (2-[(2,3-dimethylphenyl) amino] is an importantnon-esteroideal anti-inflammatory drug used to treat several pathologies [1]. It is used in cases of mild to moderate pain, including a headache, dental pain, post-operative and post-partumpain, anddysmenorrhoeae, in musculoskeletal and joint disorders such as osteoarthritis [2] The anti-inflammatory effect of MFA is due to the inhibition n of the production of prostaglandins formed by cyclooxygenase (COX) enzymes. Mefenamic acid (MFA) has been associatedwith rare but severe cases of hepatotoxicity, nephrotoxicity, gastrointestinal toxicity, and hypersensitivityreactions that arebelieved to result from theformation of reactive metabolite [3] In the case of overdose mefenamic acid in the body, it is oxidized by the P450 enzyme and the resulting oxidation product in the body can cause many complications for humans. Due to the procedure similarity of the electrochemical oxidation of mefenamic acid with its biological oxidation in the body, in this work, the electrochemical oxidation of mefenamic acid under different conditions will be investigated and it is expected that we can obtain the pKa belong to this drug by the electrochemical method by means of collected information. Then, the possible products of mefenamic acid oxidation will be synthesized alone and in the presence of nitriteion and will be identified by the IR and NMR spectra.
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