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Title
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Synthesis of bis-coumarins over acetic acid functionalized poly(4-vinylpyridinum) bromide (APVPB) as a green and efficient catalyst under solvent-free conditions and their biological activity
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Type
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JournalPaper
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Keywords
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Functionalized poly(4-vinylpyridinum) bromide · Bis-coumarin · Solvent-free · Anti-inflammatory · Antioxidant
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Abstract
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In this work, acetic acid functionalized poly(4-vinylpyridinum) bromide as a green and reusable catalyst was successfully tested on the synthesis of various bis-coumarins under solvent-free conditions. In addition, antioxidant and anti-inflammatory activities of the synthesized bis-coumarins were in vitro screened by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and formalin-induced edema model system, respectively. Antifungal activity was also evaluated against Fusarium oxysporum. Results showed that the synthesized bis-coumarins studied possess strong antioxidant ( IC50; 0.149 ± 0.005 to 1.348 ± 0.006 mg/ ml) and anti-inflammatory activities in comparison with ascorbic acid and diclofenac as positive controls, respectively. Also, the compounds showed good inhibition activity against Fusarium oxysporum (58 ± 1.4 to 100 ± 0.0%). For their biological activities, the synthesized bis-coumarins may be suggested to apply as biological agents for special use in future.
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Researchers
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(Not In First Six Researchers), siamak yari (Not In First Six Researchers), Mostafa Asadbegy (Not In First Six Researchers), Roya Karamian (Fifth Researcher), (Fourth Researcher), ma z (Third Researcher), First-Name Last-Name (Second Researcher), (First Researcher)
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