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Title
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Genome-wide association study to identify genomic regions affecting prolificacy in Lori-Bakhtiari sheep
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Type
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JournalPaper
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Keywords
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GWAS, litter size, reproduction, luteinizing hormone, SNP
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Abstract
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Several causative mutations in candidate genes affecting prolificacy have been detected in various sheep breeds. A genome-wide association study was performed on estimated breeding values for litter size in Lori-Bakhtiari sheep. Prolific ewes with twinning records and others with only singleton records were genotyped using the medium-density Illumina Ovine SNP50 array. Four single nucleotide polymorphisms (SNPs) associated with litter size were identified on chromosomes 3, 6 and 22. The region on sheep chromosome 3 between 75 739 167 and 75 745 152 bp included two significant SNPs (s52383.1 and OAR3_80038014_X.1) in high linkage disequilibrium with each other. The region that surrounds these SNPs contains a novel putative candidate gene: luteinizing hormone/choriogonadotropin receptor (LHCGR), known to be involved in ovarian steroidogenesis and organism-specific biosystem pathways in sheep. Known prolificacy genes BMPR1B, BMP15 and GDF9 were not associated with litter size in Lori-Bakhtiari sheep, suggesting that other biological mechanisms could be responsible for the trait’s variation in this breed.
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Researchers
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Cedric Gondro (Fifth Researcher), Pouya Zamani (Fourth Researcher), Navid Gavi Hossein-Zadeh (Third Researcher), Seyed ziaedin Mirhoseini (Second Researcher), Ramin Abdoli (First Researcher)
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