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Abstract
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In the past decade, the synthesis of superparamagnetic nanoparticles has been intensively developed not only for its fundamental scientific interest but also for many technological applications: among others, magnetic storage media [1]. In this study magnetic iron oxide nanoparticles (MIONPs) were modified with Si-based linker, which resulted in formation of chlorine groups on the particles surface. The chlorine functionalized MIONPs can bind to chitosan [2-3]. The obtained nanomaterials were characterized by several techniques including fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), vibrational sampling magnetometer (VSM), fieldemission scanning electron microscope (FE-SEM), energy-dispersive X-ray spectroscopy (EDX) and thermogravimetric analysis (TGA). The (Nevirapine = NEV) NEV-loading efficiency determined by UV–Vis spectrometer. The controlled delivery effect of Chitosan@MIONPs was tested for nevirapine in different conditions. The results show the high drug loading and the low release time for the prepared nanomaterials. The prepared NEV-grafted magnetic nanoparticles showed a superparamagnetic property with a saturation magnetization value of 35.7 emu g−1, indicating an unlimited potential application in the treatment of cancer using magnetic targeting drug delivery technology.
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