Research Info

Title	Synthesis of Activated Cyclopropanes by MHIRC Strategy: A Facile and Efficient Approach to Spirocyclopropanes Using N-Halosulfon­amides
Type	JournalPaper
Keywords	cyclopropane; indane-1,3-dione; Michael addition; N-halosulfonamides; ring closure; spirocycles
Abstract	In this study, a one-pot, three-component reaction of two molecules of indane-1,3-dione with aromatic aldehydes for the synthesis of spirocyclopropylindanediones using poly(N-bromo-N-ethylbenzene-1,3-disulfonamide) (PBBS), N,N,N',N'-tetrabromobenzene-1,3-disulfon­amide (TBBDA), poly(N-chloro-N-ethylbenzene-1,3-disulfonamide) (PCBS), and N,N,N',N'-tetrachlorobenzene-1,3-disulfonamide (TCBDA) as novel reagents has been developed. In addition, an effective and simple domino procedure for the preparation of spirodicyanocyclopropylindanediones from indane-1,3-dione and 2-arylidenemalononitriles is reported. These reactions involve Michael addition, halogenation, and intramolecular ring-closing (MHIRC) reaction sequences. © Georg Thieme VerlagStuttgart · New York.
Researchers	(Second Researcher), Ramin Ghorbani-Vaghei (First Researcher)