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Title
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EVALUATION OF EXPRESSION OF TNF-Α, IL1-Α, IL1-Β PRO- INFLAMMATORY GENES IN LIVER LEISHMANIA INFECTED BALB/C MICE
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Type
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Presentation
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Keywords
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Leishmania, pro-inflammatory genes, liver,BALB/c mice
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Abstract
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Background and Aim: Leishmaniasis is a disease with different clinical symptoms. This study focuses on expression of pro-inflammatory gene. Investigating the expression of cytokines, especially in the liver, can be important in detecting the profile of inflammatory genes in cutaneous leishmaniasis. Methods: Expression of these pro-inflammatory genes including IL-1α, IL-1β, TNF-α was analyzed using by RT-PCR in liver Leishmania infected BALB/c mice. Results: Pro-inflammatory genes, including TNF-α, IL-1β were expressed in mice infected liver. Conclusion: Current study indicated a role for Leishmania in expression proinflammatory genes in livers of infected mice.
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Researchers
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Elham ghiyasvand (Fourth Researcher), Maryam Hamze (Third Researcher), sahar hamoon navard (Second Researcher), Hossein Rezvan (First Researcher)
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